Syringe Filters, 25mm, PTFE, 0.45um Pore Size. Yellow Polypropylene, AQ Brand. 50/PK.
Additional Info:
The 58045-P25-A AQ™ Syringe Filters are pharmaceutical-grade, high-performance membrane filters engineered for HPLC sample preparation and dissolution testing in regulated laboratory environments. Featuring a 0.45 µm PTFE (Polytetrafluoroethylene) membrane, these filters provide exceptional chemical resistance, high flow rates, and extractable-free performance, ensuring reliable and reproducible chromatographic results.
PTFE membranes are the preferred choice for organic solvents, offering superior chemical durability and resistance to aggressive solvents, acids, and bases, making them ideal for demanding analytical workflows.
✅ Critical Compliance Advantage (No Flush Required)
These filters are validated and certified to meet stringent regulatory requirements, including:
US FDA CFR Title 21, Part 211.92 for minimum fiber release
USP <788> for particulate matter in injectables
USP requirements for “Sterile Water for Injection”
Because of this validated performance:
✅ No initial flushing is required
✅ No need to discard the first 200 µL of filtrate
✅ Preserves valuable samples
✅ Eliminates a common source of failed methods and investigations
👉 This provides a major operational and compliance advantage for QC/QA laboratories, especially in regulated environments using costly or limited solvent systems.
Performance & Design
The 0.45 µm pore size is optimized for sample clarification and prefiltration, delivering high flow rates with minimal clogging, ideal for routine and high-throughput workflows.
PTFE membrane chemistry provides maximum chemical compatibility, making it the best choice for organic solvents, strong acids, and aggressive chemical systems.
⚠️ Note: PTFE filters are not recommended for 100% aqueous or buffer solutions due to hydrophobic membrane characteristics.
The advanced 16-channel outlet design minimizes back pressure, allowing smooth filtration with reduced hand force, improving ergonomics and consistency in repetitive workflows.
The 25 mm format supports larger sample volumes and high-throughput applications, while the yellow housing allows easy identification of 0.45 µm PTFE filters.
Each pack includes a Certificate of Analysis, ensuring full traceability and regulatory compliance.
Key Features
0.45 µm PTFE Membrane (Pharma Grade)
Ideal for organic solvent filtration
High flow and chemical durability
✅ No Initial Flush Required (Validated)
Extractable-free from first filtrate
No 200 µL discard required
Superior Chemical Resistance
Compatible with strong solvents, acids, and bases
Will not degrade under harsh conditions
⚠️ Hydrophobic Membrane
Not recommended for 100% aqueous solutions
Best suited for organic or mixed-phase systems
High Throughput Performance (25 mm)
Handles larger volumes
Supports routine and high-volume workflows
Advanced 16-Channel Outlet Design
Reduces back pressure
Minimizes user hand force
Low Extractables
Provides clean chromatographic baselines
Supports reproducibility
Regulatory Compliance
Meets FDA CFR 21 (211.92) requirements
Complies with USP <788>
Suitable for Sterile Water for Injection
Color-Coded (Yellow)
Identifies 0.45 µm PTFE filters
Typical Applications
HPLC & UHPLC Sample Preparation – organic solvent filtration
Organic Solvent Systems – aggressive chemical compatibility
Pharmaceutical Analysis – dissolution and QC testing
Environmental & Chemical Testing – harsh solvent conditions
Industrial Laboratory Applications – strong chemical workflows
Regulated Laboratory Methods – validated, compliant processes
Specifications
Filter Type: Syringe Filter (Pharma Grade)
Membrane Material: PTFE (Polytetrafluoroethylene)
Pore Size: 0.45 µm
Diameter: 25 mm
Housing Material: Polypropylene (PP)
Color Code: Yellow (0.45 µm PTFE)
Connection Type: Luer Lock / Slip
Chemical Compatibility: Organic solvents, acids, bases
Hydrophilicity: Hydrophobic (not for aqueous solutions)
Extractables: None detectable (no flush required)
Sterilization: Autoclave or EO
Compliance: FDA CFR 21 (211.92), USP <788>
Certification: Certificate of Analysis included
Sterility: Non-sterile
Pack Size: 50/PK
Brand: AQ™
Resources & Ordering Options
Purchase PTFE syringe filters, 0.45 µm, 25 mm – 100/pack quantity
Order PTFE syringe filters, 0.45 µm, 25 mm – 1000/case quantity